Putting a bird on Prozac is pretty extreme. I'm not going to say that it's never appropriate, but in my opinion it's a last resort.
My brown-headed parrot is a rescue and he started plucking out of nowhere last October. Long story short we tried everything. My avian vet knows I take good care of him and she said, "Usually when someone has a plucking bird I can say, 'Their diet is poor or they don't get enough sunlight or they don't have enough toys or they don't have enough out-of-cage time.' I know that's not the case with your bird so all I really have left to recommend at this point is Prozac. Let me know if you want to take that route."
I went home and did some research and decided against it mainly because at this point in time it's unknown whether birds' brains work the same way ours do (in regards to levels of serotonin affecting mood and behavior) and Prozac is a strong drug with (potentially) serious side-effects. That being said, some plucking birds apparently have responded to SSRIs (like Prozac) but it's used so rarely that sample sizes are too small to determine how effective it is.
You can try a few other (less extreme) things first and if those don't help, you can always try Prozac later. Here's some things I tried with my bird, to no success, but I read that other plucking birds responded to this:
1.
Bach Rescue Remedy Pet. This was recommended by my vet and is a "natural remedy made from flower essences. It helps restore inner calm." It is added to water.
OR
2.
AviCalm. This is also added to water (or food) and is "an avian specific formulation using a compound found in green tea leaves for use in screamers, nervous, or aggressive birds."
3. Aloe vera sprays. Mix aloe vera juice (
not gel) and distilled water in a spray bottle. Four parts water to one part aloe is a good starting point and it can be made stronger or weaker if needed. Spray your bird several times a day with this mixture. Sometimes this alone stops plucking.
4. Sunlight and/or full-spectrum lighting. Some birds pluck because they aren't getting enough exposure to UVA/UVB. If your bird isn't getting a "daily dose" of direct sunlight (windows filter out UVA/UVB) this could help.
5. A mop head. Some birds have stopped plucking when given a "substitute" object to mutilate, such as a mop head. Make sure it's just a plain, cotton mop head that doesn't have any fancy, deadly chemicals (some of the mop heads I saw had anti-microbial 'treatments' applied to the mop).
Now, last but not least, here is something that did help my plucker: clicker training. He does not know recall yet (I have been working on that with him for about a month and a half) but he does know how to target, turn in a circle, and wave. He hasn't stopped plucking, but I noticed an almost immediate, HUGE improvement in his plucking once I started training him every day.
Once your bird knows "click means treat" you can actually use this to try to address plucking as well. This doesn't work with my bird because he only plucks at night (when he should be sleeping) but since your bird is plucking during the day this could improve or stop the behavior: whenever you're with your bird, ignore the plucking. If your bird goes say, a few minutes
without plucking, click and praise and treat. Throughout the day you'll want to periodically reward the bird when you notice that it's
not plucking.
Additionally, you can use clicker training to try to encourage your bird to play with its toys again. You teach your bird to "target" and then you use the target stick to show the bird you want it to just touch a toy with its beak. Then you click and reward the bird when it touches the toy. Pretty soon the bird will figure out that if it touches a toy with its beak it will get a treat, so it should start doing this more often. The bird may eventually start to interact with its toys more often because of this, and if you see it playing with a toy you click and treat, etc.
Target Training Parrot Outside the Cage - Michael explains all there is to know about clicker training.
Flight Recall Michael demonstrates teaching flight recall to Truman.